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Similar content being viewed by others Subjects Introduction Copper, an essential trace element crucial for various physiological processes, has garnered increasing attention for its intricate role in cancer biology
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Fucoidan-selenium nanoparticles (FD-SeNPs) induced ferroptosis in hepatocellular carcinoma cells through downregulation of the Nrf2/HO-1 and SLC7A11/GSH/GPX4 pathways, characterized by elevated ROS, MDA, and Fe 2+ levels, reduced GSH, mitochondrial shrinkage and cristae disruption, upregulation of ferroportin, and downregulation of SLC40A1 and Ferritin, ultimately disrupting iron homeostasis (Chen et al., 2025a)
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