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The peptide’s half-life in vivo is short due to rapid metabolism, which is why repeated administration or formulation stabilization is needed in experimental settings

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An in vitro AlphaScreen technology binding assay showed that IACS-16898 is a potent inhibitor of CREB-binding protein (CBP), the paralog of p300, with an IC 50 of 3 nM versus a reported IC 50 of 4790 nM for BRD4 (Fig