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Multiple myeloma cells’ resistance to bortezomib, a proteasome inhibitor, is associated with the S-glutathionylation of the binding immunoglobulin protein (BiP), with Cys41-SSG being important for ATPase and Cys420-SSG for foldase [291]
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Therefore, future research should focus on optimizing these formulation technologies to improve their effectiveness and safety in clinical applications
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