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With multiple well-designed randomized controlled trials of nicotinamide, metformin, semaglutide, ONL1204, and CNTF now underway, the next five years may prove decisive in determining whether IOP-independent neuroprotection becomes a clinical reality in glaucoma management

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[DOI] [PMC free article] [PubMed] [Google Scholar] Yang HP, Zeng Y, Lee TD, Yang T, Ou XP, Chen LX, Haque M, Rippe R, Lu SC