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[8],[25],[26],[27] Rarely generalized argyria has been documented either with prolonged use of silver dressings/cream or application over large body surface area such as in cases of burns, epidermolysis bullosa and venous leg ulcers

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For instance, glutamine depletion diminishes CD8 + T cell effector responses, while enhanced one-carbon metabolism may favor regulatory T cell (Treg) differentiation, suppress inflammation, and contribute to viral immune escape [109,110]