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The authors also reported that mouse embryonic fibroblasts of PAD4 knockout mice showed increased FUS aggregation and sequestration into SGs compared with PAD4 overexpression cells, indicating that citrullination inhibits FUS phase separation 113

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Para el contexto gastrointestinal, la estabilidad gástrica del péptido ha hecho que la vía oral sea objeto de estudio en animales, a diferencia de otros péptidos que requieren inyección