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Though the recommended doses are not expected to cause adverse effects for the infant, there are no human studies available to assess the risks

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They include the production of IL-6 and TGF-β that directly stimulate collagen synthesis in human dermal fibroblasts (63), synthesis of antifibrillin antibodies that activate fibroblast activity (64), generation of anti-endothelial antibodies causing vessel damage and inflammation (65), and secretion of antibodies against MMP3 in the ECM (66)

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