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Moreover, the fact that these proteins are within the lipid layer obliges the use of detergents to enhance their solubilization in aqueous systems, which influences the purification step due to detergent interference in ion-exchange and hydrophobic chromatography (Lin and Guidotti, 2009, Smith, 2011)

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This finding gives an improved understanding of the role played by ferroptosis in cancer, which might generate opportunities for diagnostics and therapeutic interventions for GCs