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Additional studies are required to fully understand these molecular mechanisms of MOR regulation that underlie acute analgesic tolerance, but the current results suggest that opioids can either use a GRK-arrestin–dependent mechanism or a PKC-JNK dependent mechanism to produce MOR desensitization and short-term analgesic tolerance

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[DOI] [PubMed] [Google Scholar] 128.Mishina Y.V., Krishna S., Haynes R.K., Meade J.C