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Factors capable of denaturing proteins include but are not limited to: Hot & Cold Temperatures pH Extremes Ultra-Violet Exposure (Sunlight Radiation) Mechanical Agitation In searching storefronts in hopes of finding the best grass-fed whey protein, you will most likely spot a label that states something to the effect, "Undenatured Whey Protein" or even "Non-denatured Whey Protein." This claim is becoming as popular as "Cold Processed" & "Grass-Fed." The idea behind the marketing point is a suggestion that careful sourcing, manufacturing, and handling is given to the protein to ensure the protein structures are entirely intact