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“As is true for many of the vitamins discovered in the early 20th century, the effects of B12 seemed miraculous,” Heber explains

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This could occur through direct methylation of Met4, or indirectly through methylation of the DNA-binding cofactors assisting Met4 recruitment or the ubiquitin-ligase SCF Met30 known to downregulate Met4 activity and stability 61,62,65,66