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Several research findings suggest that oxidative damage resulting from disproportion between reactive oxygen metabolites (ROMs) production and antioxidant activity generates deleterious effects on signal transduction, mitochondrial complex (I-IV) activities, structural plasticity, oxidation of proteins, and lipid peroxidation in membranes and genes leading to neuronal death (Takuma et al., 2004)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Asrani S., Bacharach J., Holland E., McKee H., Sheng H., Lewis R.A., Kopczynski C.C., Heah T