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In tumors, loss of inhibition, together with the presence of tumor-associated activating ligands (e.g., MICA, MICB, and ULBP), triggers a cytotoxic response against tumors with low MHC expression

gltathione

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Considerations such as the selection of growth factor, its rate of release in the artificial tissue environment, the half-life of growth factor in the body, and how it is excreted in tissue should be considered