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Since oxalate can combine with various plant ions to from soluble or insoluble compounds, oxalate has been suggested to balance the excess of various inorganic cations (such as K + , Na + , NH + 4 , Ca ++ , and Mg ++ ) over anions (such as NO − 3 , Cl − , H 2 PO − 4 , and SO 2− 4 ) (reviewed by Çalişkan, 2000)

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178 Meanwhile, arginine deprivation promotes GCN2-dependent cycle arrest in HCC cells, and inhibition of GCN2 in arginine-deprived HCC cells promotes cellular senescence and increases the efficacy of senolytic compounds (Fig