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This is because total T3 levels fall later than FT4 levels in the course of development of hypothyroidism due to enhanced T4 to T3 conversion, and also because T3 levels are lowered by illness, poor nutrition, starvation, fasting, and several drugs such as β-blockers and glucocorticoids

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Roncal-JimenezCAMilagresTAndres-HernandoAKuwabaraMJensenTSongZet al