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Animal studies have documented significant improvements in Morris water maze performance, radial arm maze accuracy, and novel object recognition tasks, with effects persisting for extended periods after treatment suggesting lasting changes in neural connectivity rather than temporary pharmacological stimulation
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This reaction has two consequences studied in the literature: it consumes S-adenosyl methionine, the cell’s principal methyl donor, and it removes nicotinamide from the salvage pathway that regenerates NAD+
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