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is that patients with intracranial hypertension correlate with high levels of extracellular glutamate in brain.21 Using different models of liver injury, glutamate concentration was found increased in brain tissue and cere-brospinal fluid22,23 in hepatic devascularization24 and in animals exposed to acute hyperammonemia.25 Interestingly, mild hypothermia in rats prevents the initiation of encephalopathy and brain edema, with a decrease in extracellular brain glutamate.26,27 The NMDA receptor Glutamate has two main types of receptors: ionotropic and metabotropic

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Actin is a highly abundant cellular protein that forms the microfilaments crucial to cellular structure, division, and movement