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FDA-approved Semaglutide is an analog of one such gut hormone called glucagon-like peptide-1 (GLP-1), a “multifaceted hormone with broad pharmacological potential [that exerts] numerous metabolic effects [such as] glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of… β-cell proliferation.” Hormone replacement therapy (HRT) can help you get off that treadmill to nowhere and start making real, sustainable weight loss progress

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Phase 2b clinical trials were completed in Australia testing the drug in 300 obese individuals