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Methylcobalamin helps in the production of SAM-e (S-adenosyl methionine), a compound that affects mood and emotional well-being
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Dimet-Wiley, Wu, and colleagues, also publishing in Scientific Reports in 2022, found that NNMT inhibition combined with calorie restriction altered gut microbiome composition in diet-induced obese mice — suggesting systemic metabolic effects that extend beyond adipose tissue, though the clinical significance in humans is unknown
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