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Across a development program covering more than 6,000 participants, nosebleeds appeared in fewer than one percent of cases with no dose-dependent pattern, and they were not classified as a serious or common adverse event requiring a black-box warning or special monitoring

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Body Composition & Fat Reduction Studies demonstrate that NNMT inhibition leads to reduced adiposity and improved metabolic flexibility without the need for stimulant-based interventions¹⁻³