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In addition, Glu has the following features: chemical stability, metabolic generation and easy removal (interconversion with α-ketoglutarate), negative charge (at physiological pH value), and acidic amino acid [due to its two carboxyl groups (α- and γ-carboxyl) and one amino group]

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Scientific evidences have unanimously established the role of zinc ions in modulating glutaminergic synapse transmission (Bertoni-Freddari et al., 2008)