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This increased demand can potentially create relative deficiencies in these co-factors, even if their levels were previously adequate
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Figure 6 ADO concentrations in the BM niche are regulated not only by the CD38/CD203a/CD73 pathway ( Figure 1 ) but also by clearance mechanisms (86, 87): ADA, anchored to CD26 on MM cells and infiltrating lymphocytes (83), converts excess ADO into INO
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