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While coeliac disease may be considered an uncommon cause of growth retardation, rates of up to 15% of children with short stature have been reported (46, 47) and diagnosis is often delayed (48)

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Another strategy to achieve inhibition of mTOR uses a modulator of the mitochondrial pyruvate carrier (MPC) called MSDC-0160 to reduce pyruvate transport into the mitochondria

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