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136 ATF4 plays a dual role in inhibiting or promoting ferroptosis through the upregulation of SLC7A11 , SLC1A5 , DNA damage-inducible transcript 3 ( DDIT3 / CHOP ), HSPA5 , tribbles pseudokinase 3 ( TRIB3 ) and ChaC glutathione-specific gamma-glutamylcyclotransferase 1 ( CHAC1 ) in human glioblastoma, pancreatic cancer, or Burkitt’s lymphoma cells
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Figure 1 To elucidate these emerging insights, this review focuses specifically on hypothyroidism, rather than thyroid disorders in general, and synthesizes current knowledge on the mechanistic, clinical, and therapeutic implications of gut microbiota in this context