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Dies führt zum Anstieg des Homocysteinspiegels und zur Abnahme der Methylierungsprozesse, da die Produktion von 5-MTHF insbesondere bei einer geringen Folateinnahme abnimmt.(3) In der Leber, den Nieren und den Augen wird Homocystein noch über Betain und das Enzym BHMT (Betain-Homocystein-Methyltransferase) recycelt, aber dieser Prozess gerät unter großen Druck