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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the α-helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes
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Both peptides are typically supplied as lyophilized (freeze-dried) powder that the patient or pharmacy reconstitutes with bacteriostatic water
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