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Three naturally occurring microbiome-derived toxins—indoxyl sulfate (IS), p-cresyl sulfate (pCS), and trimethylamine N-oxide (TMAO)—are linked to the development of cardiovascular disease, the worsening of kidney disease, and death from these conditions (61, 62)

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HSP-70 in a complex together with Bag-1 degrades the denatured protein, and the Bag-1/HSP-70 complex also has an antiapoptotic function 259