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The cysteine modification is expected to trigger a conformational change of the Keap1 homodimer, which could dissociate the weak binding site, the DLG motif (latch), from the Keap1 DC domain, while the strong binding site, the ETGE motif (hinge), remains attached to the other Keap1 DC domain

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Remarkably, NSCs differentiated into astrocytes, as indicated by glial fibrillary acidic protein expression, and mature neurons, as neuronal nuclei (NeuN) were expressed (Jing et al., 2009)