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Predrag Sikiric’s group (School of Medicine, University of Zagreb, 1991 ) Most common experimental dose in animal studies: 10 μg/kg intraperitoneally or per os, daily Standard targeted pathways: VEGFR2 angiogenesis, NO synthase , 5-HT2A serotonin receptor, dopamine D2 receptor Clinical program in Croatia halted at Phase 2 (Crohn’s disease) WADA Prohibited List: added in 2022 to category S0 (Non-Approved Substances) Reference sources (PubMed) Sikiric P

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Right-upper-abdominal pain, fever, vomiting, or jaundice usually requires medical evaluation and often ultrasound or other imaging