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Thus, if a substance is unclassified because no specific target organ toxicity was seen at or below the dose/concentration guidance value for animal testing, if subsequent human incident data become available showing a specific target organ toxic effect, the substance shall be classified
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As illustration, these might be an anti-reflux effect (i.e., BPC 157 increased lower esophageal sphincter pressure, and decreased pyloric sphincter pressure [107]), the maintenance of normal pupil diameter [116], or the maintenance of normal leak point pressure [117]
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