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Third, most inhibitors of NLRP3, NF-κB, autophagy, ferroptosis, or senescence remain preclinical and lack regulatory approval, and there is a paucity of validated pharmacodynamic biomarkers in humans (e.g., CSF IL-1β/IL-18, GSDMD-N, ex vivo NLRP3 assays) to confirm target engagement

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Khan H., Singh T.G., Dahiya R.S., Abdel-Daim M.M