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glutathione levels in cancer cells Human cancer-associated fibroblasts enhance and antagonize drug-induced prostate cell death Glutathione in the tumor and –

Once ROS overwhelms the antioxidant activity of the cell, oxidative stress occurs ( in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 ( Studies have found that berberine has an antidepressant effect (Figure 1)

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In vitro studies showed that H37Rv strain is sensitive to GSH, highlighting its potential for intracellular M.tb control [93]