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35 Moreover DOX-induced kidney impairment was detected by increased BUN and SCr levels these renal function parameters are dependable and highly sensitive markers of drug-induced nephrotoxicity, 34,36 importantly in the present study, DOX administration resulted in a significant decline in renal function as manifested by increased SCr and BUN levels in the DOX control group when compared to the NC group, and these results align with previous studies
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