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Earlier biguanides such as phenformin and buformin showed greater potency but were withdrawn from the market due to a high incidence of lactic acidosis (LaMoia and Shulman, 2021)

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*Correspondence: Gad Elsayed Mohamed Salem, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers