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9.1.12 Summary of evaluation 9.1.12.1 Indications Methylene blue is the agent of choice for accelerating the reduction of methaemoglobin, at toxic levels, induced by aniline and aminophenols, nitrites and nitrates, nitrobenzene, antimalarial agents (chloroquine, primaquine), dapsone, local anaesthetics (lidocaine, prilocaine, benzocaine), phenacetin, phenazopyridin, and sulfamidines