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Black pepper (Bioperine) can raise blood levels of several drugs — propranolol, nevirapine, rifampin, phenytoin, cyclosporine, pentobarbital, atorvastatin, and theophylline — all at Moderate severity
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Sleep disorders like restless legs syndrome, periodic limb movement disorder, and circadian rhythm disorders can coexist with tirzepatide treatment and require separate diagnosis and management
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