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Large, controlled clinical trials are needed to establish a safe formulation, and a safe and effective dose, and to determine if these substances are risky for people with certain health conditions or with long term use

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Nrf2 regulates glutathione gene expression through the ARE Detailed in silico analysis of the 2-kb promoter region 5′ upstream of the translational start site of the mouse GSR genomic locus was performed using the core ARE sequence RTGAYNNNGCR with the help of Genamics Expression 1.1 software as previously described [28]