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First, bacterially produced GLP-1 often exhibits incomplete length or atypical processing because microorganisms lack the prohormone-convertase machinery (PC1/3, PC2) characteristic of enteroendocrine L-cells ( 2+ signaling, and coordinated enteroendocrine regulation ( 10 Conclusion Current evidence indicates that the functional heterogeneity and adaptive potential of β-cells in T2D are shaped by both intrinsic molecular programs and extrinsic regulatory cues, among which signals originating from the gut microbiota are particularly prominent

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References Dufour, C.R., et al