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These requirements usually include: The laws in their state or region allow it They’ve completed proper training on how to give injections safely They have direct permission and supervision from a doctor or registered nurse Medical assistants typically give these types of injections: Intramuscular (IM) — like vaccines or B12 shots Subcutaneous (under the skin, SubQ) — like insulin Intradermal (ID) — like allergy tests But some injections are off-limits for medical assistants, including: IV (intravenous) injections Botox or other cosmetic shots Anesthesia or strong medications These more complex injections usually require a nurse or doctor to perform them