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In the year after withdrawal, the semaglutide group regained 11.6 percentage points of that loss, finishing at 5.6% below their starting weight, and the cardiometabolic improvements they had gained drifted back toward baseline for most variables alongside the weight

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Peptides have existed as potential drug candidates for decades, but the process of linking the amino acids in the correct sequence — requiring repeated chemical reactions and purification — made them difficult to manufacture and incredibly labor-intensive, Kates said