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Clozapine is quickly metabolised to NDMC (metabolite N-desmethylclozapine) in mice but slowly metabolised to CNO and NDMC in rats these outcomes may help explain why different species have different reactions to CNO

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System Xc - , which is a heterodimeric transmembrane transporter consisting of the light chain xCT (SLC7A11) and heavy chain 4F2hc (SLC3A2) (Koppula et al., 2018), facilitates the exchange of cystine and glutamate at a 1:1 ratio (Liu et al., 2021)

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