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Less frequently, melatonin use has been associated with psychiatric issues such as anxiety and depression, skin conditions like rashes and maculopapular eruptions, and gastrointestinal problems including constipation, nausea, and, in rare cases, acute pancreatitis [228,229,230,231,232]
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Targeted Immunotherapy: With the discovery of specific immune pathways like the NLRP3 inflammasome involvement, researchers are developing treatments that precisely target these mechanisms without broadly suppressing immunity [5]
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