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K., Priyadarsini K
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Contradictory reports exist regarding the role of PARP-1 genetic variants in PD [40, 140], but a number of studies have suggested that PARP-1 activation upon PD-related insults leads to energy depletion associated to the consumption of ATP by the NAD + salvage pathway, and subsequent neuronal cell loss with necrotic characteristics (Parthanatos) [143, 144, 164, 181, 185, 195, 211, 252, 338, 350]
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