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doi: 10.1093/jn/131.3.1109S
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The barrier functions of esophageal squamous stratified epithelium involve providing mucosal and submucosal defense against noxious intraluminal substances and regulating paracellular ion transport, which is mediated by claudins, the tetra-spanning transmembrane proteins of tight junctions, located at the apical and lateral membranes of esophageal epithelial cells
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