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A recent in vivo study in gilthead sea bream showed that the administration of a sustained–release formulation of recombinant bovine GH significantly reduced pituitary GH mRNA ( As mentioned earlier, the gradual decrease in complexity in the regulation of somatotrophs during vertebrate evolution (103)

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In eukaryotic cells, mitochondria, the cytochrome P450 (CYP) enzyme system, peroxisomes, and NADPH oxidases (NOXs) are the main contributors to ROS generation [18,19,20,21,22]