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In clinical gastroenterology, "leaky gut" is not a primary medical diagnosis like Crohn's disease or celiac disease.Increased intestinal permeability is a secondary consequence of underlying inflammation, dietary triggers, or microbiome dysbiosis
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Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (NAM) with the methyl donor S-adenosyl-methionine (SAM) to form methylnicotinamide (MNAM) and S-adenosyl-l-homocysteine (SAH) (Van Haren et al., 2016)
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