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The researchers concluded that MOTS-c “may serve as a promising therapeutic target for inflammatory pain.”23 Bone growth “MOTS-c promotes osteoblast proliferation, differentiation, and mineralization,” say the authors of a 2023 review.24 Osteoblasts, by the way, are cells that both form new bones and heal existing ones — the more of them you have, the stronger and denser your bones are likely to be.25 So MOTS-c’s osteoblast-promoting action is great news for anyone at high risk of developing osteoporosis, such as postmenopausal women.26 Quality of life Each of the health concerns we’ve addressed here — metabolic dysfunction,27 increased body fat,28 decreased physical capacity,29 increased inflammation,30 and reduced bone density31 — often correlates with advanced age, so it follows that attenuating these factors would result in a more robust and enjoyable aging experience

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Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis