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Additionally, its progression is influenced by inflammation, the renin-angiotensin system (RAAS), advanced glycation end-product (AGE) formation, and signaling molecules, including transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), PKC, MAPK, and ROS

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Lysosomal function Lysosomes are organelles within cells that are specialized for the digestion of cellular debris