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Informed by quantum theory, Pauling combined his observations made by X-ray crystallography with complex mathematical calculations to develop generalizations about crystal structures, formulating “Pauling’s rules” for atomic arrangements in crystals with ionic bonding

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Conversely, cells incubated with higher curcumin concentrations (10, 20, and 50 µM) underwent marked morphological changes, rounding and detachment from the culture substrate, indicative of cell death