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The Metabolic Pathway from Tryptophan to KYNA Although a proper assessment of the flux to KYNA using metabolic control analysis (see [103,104,105,106,107]) seems not to have been performed, ODE-based mathematical modelling of the overall pathway has been [108], the interactions with vitamin B6 (pyridoxamine/pyridoxal) being of particular interest from a nutritional point of view as this is a cofactor for the KAT reaction